The Relationship Between Copeptin Level and Enuresis in Children Aged 5 - 15 Years

Background: Enuresis is bedwetting that occurs during sleep in children over five years old. If left untreated, it can lead to social and psychological problems for their parents. The role of copeptin patients with primary monosymptomatic nocturnal enuresis (PMNE) has been reported several studies. Due the favorable structural properties reflection arginine vasopressin (AVP) concentration, be used as an alternative marker AVP secretion. Objectives: This study aims compare levels healthy aged 5 - 15 years. Methods: case-control was performed on 42 without who were referred clinic Taleghani hospital Gorgan 2020. Copeptin measured by enzyme-linked immunosorbent assay (ELISA) method. Results: Out 84 patients, equal proportion girls (21 patients) boys participated both case control groups. age 8.05 ± 2.46 years, there no statistically significant difference between two groups (P = 0.16). mean level 6.7 4.27 6.87 8.52 pg/mL, respectively, significantly lower group 0.03). There a Although patient than group, this not 0.35). Conclusions: In study, PMNE which suggests may considered probable biomarker prediction response treatment desmopressin, but further required confirm hypothesis.